Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding. ASCOT-BPLA is one of the first major studies to compare combination antihypertensive regimens. Although the trial design started patients with. ASCOT-BPLA Trial Overview. ♢ a multi-center randomized placebo-controlled trial to determine effects of amlodipine +/- perindopril vs atenolol.

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This study was started about 6 years ago and compared the blood pressure lowering effects of Atenolol with Bendroflumethiazide to those of Amlodipine with Perindopril.

Intensive blood pressure lowering regimens had been shown in multiple randomized control trials to reduce cardiovascular moribidity and mortality. Our aim, therefore, was to compare the effect on non-fatal myocardial infarction and fatal CHD of combinations of atenolol with a thiazide versus amlodipine with perindopril. The amlodipine-based regimen prevented more major cardiovascular events and induced less diabetes than the atenolol-based regimen.

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ASCOT – BPLA – Prescribing Advice for GPs

The outcomes of the study could be entirely driven by greater reductions in blood pressure that occurred in the Amlodipine arm. This blog is maintained by Matthew Robinson. This process is likely to take six months.

Secondary outcomes suggest a possible reduction in cardiovascular morbidity and mortality using amlodipine and perindopril, although this may be ascribed to differences in blood pressure between the two study arms.

Accept No thanks Read more. Among hypertensive patients at high risk of cardiovascular disease, does a combination regimen of amlodipine and perindopril prevent more cardiovascular events than atenolol and bendroflumethiazide?

The lack of statistical significance may have been due to early trial termination, as the trial did not meet the pre-specified number of primary events of Where there was a statistical difference in the secondary outcomes, perhaps it would have been expected. At the same time the paper was released by the Lancetthey released another paper investigating the role of blood pressure and other variables in the results.

This was perhaps seen as necessary because there was a difference in the blood pressures of the two arms of 2. Our primary endpoint was non-fatal myocardial infarction including silent myocardial infarction and fatal Vpla. JavaScript is required for form validation, if you want to use this form please turn JavaScript on qscot use a different browser. If these limitations in the study are accepted does it add anything new to the body of evidence in Hypertension?

Do Not Change This: Expert Opinion — Grade E. Leave This Blank Too: It was hypothesized that adverse side effects of older antihypertensive agents, such as beta-blockers and diuretics, was partially offsetting the benefit of blood pressure reduction [1].


However, the size of benefit was significantly less than predicted compared to previous observational studies [1]. If goal BP cannot be reached with 2 drugs, add and titrate a third drug from the list provided. We did a multicentre, prospective, randomised controlled trial in 19 patients with hypertension who were aged years and had at least three other zscot risk factors. And we already know about the diabetes risk posed by the combination of Beta-blockers and Diuretics.

The main objective of hypertension treatment is to attain and maintain goal BP. On the basis of previous trial evidence, these effects might not be entirely explained by better control of blood pressure, and this issue is addressed in the accompanying article.

The media have already picked up on this new study with the BBC and newspapers like the Telegraph reporting the headline findings of the trial. Articles in the Lancet and BMJ that have already been covered on this website have also raised this discrepancy and it has [ Amlodipine and perindopril ascoot not reduce cardiovascular morbidity and mortality compared to atenolol and bendroflumethiazide.

However, the trial was underpowered as it was stopped early due to a significant reduction in all cause-mortality in the amlodipine and perindopril arm.

The clinician should continue to assess BP and adjust the treatment regimen until goal BP is xscot. This page was last modified on 15 Septemberat Nevertheless, the results have implications with respect to optimum combinations of antihypertensive agents.

A detailed appraisal of the study reveals sacot it doesn’t really add a great deal to our current knowledge. Navigation menu Personal tools Create account Log in.

Overall, this investigation found that correcting for these variables reduced the differences by about half for coronary events and by just under half for stroke events, and that neither were statistically significant after the correction.


Results 1 – 26 of 26 HOMBRE DOLIENTE, EL by FRANKL, VIKTOR E. and a great selection of related books, art and collectibles available now at El Hombre Doliente by Viktor Emil Frankl, , available at Book Depository with free delivery worldwide. El hombre doliente: fundamentos antropológicos de la psicoterapia. Front Cover. Viktor E. Frankl. Herder, – Logoterapia – pages.

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But in Why I Am Not a Secularist, distinguished political theorist William E. Connolly argues that secularism, although admirable in its pursuit of freedom and . Why I Am Not a Secularist. By William E. Connolly. Minneapolis: University of Minnesota Press, p. $ – Volume 94 Issue 2 – J. Donald Moon. Why I Am Not a Secularist has 43 ratings and 2 reviews. Katie said: I really enjoyed this book. Connolly provides a unique perspective on themes in secul.

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An Atheist and William Connolly

Social Origins of Religion A classic work that provides an essential framework for the study of the sacred. Hale – – International Journal for Philosophy of Religion 76 3: To correct these limitations, Connolly advances a bold new vision of public diversity that acknowledges questions about its own ideology, incorporates a wider variety of ethical views, and honors the desire of believers and nonbelievers alike to represent their faiths openly in the civic forum.

Women’s Music and Democratic Politics. This is the latest in a series of works in which Connolly has been interrogating liberalism and its fellow travelers.

Account Options Sign in. Nicholas Tampio connilly – Deleuze and Guatarri Studies 8 1: As far as I can see, the press, various media, colleges, libraries, and city halls have and do practice agonistic engagement with different comprehensive doctrines. Connolly demonstrates how far we still have to go sefularist understand what it means to live in a democratic society, and some of his ideas will help us come to grips with these vital and unresolved issues.

The author projects an ideal, multidimensional pluralism in which various ethnic, social, religious, and faith groups seek space in a globalized, denaitionized universe. Email alerts New issue alert. Sahara rated it really liked it Apr 08, Erin Foster rated it it was amazing Apr 27, As I understand it, secularism is what religious pluralism needs to continue.

It can lead people to accept a nice and clear story of the rise of secularism. Agreed Syllabi and Un-Agreed Values: Why I Am Not a Secularist is powerful and original.

Adrian Pabst – unknown. U of Minnesota Press seculaarist, – Religion – pages. Science Logic and Mathematics. I really enjoyed this book. In response to Connolly, I am going to argue why some of his key positions are admirable, but that some of the conclusions he draws from them are not.

To see what your friends thought of this book, please sign up. Oxford University Press is a department of the University of Oxford. Connolyl Harfouch rated it it was amazing May 15, Daniel Putman – – Philosophy 83 3: Want to Read saving…. The Secularism of Post-Secularity: It is difficult, however, to think of what Connolly has in mind here.

Just a moment while we sign you in to your Goodreads account. History of Western Philosophy. Julien Leger rated it really liked it May 20, Religion’s influence in American politics is obvious in recent debates about school prayer, abortion, and homosexuality, as well as in the success of grassroots religious organizations in mobilizing voters.

According to Connolly, modern day secularism has innumerable problems that it must face. By seeking to provide answers to the problems facing a radically diverse society, Connolly may actually be working against deep pluralism.

Not to mention Martin Luther who, in spite of his deeply held religious commitments, argued for the separation of Church and State. Challenges the limitations of traditional secularism. Allison rated it it was ok Apr 26, Mishi rated it liked it Jul 15, Constitution Writing, Religion and Democracy. To purchase short term access, please sign in to your Oxford Academic account above. This kind of shy of ssecularist voices, specifically religious voices, also creates an environment of hostility and antagonism, one that nurtures in the religious a connollh of disappointment and disdain for the secular public sphere.

Connolly first shows how the secular division between public and private life conceals the vital role of secukarist visceral register” in public life itself. Many liberal secularists decry this trend, rejecting any interaction between xecularist and religion Connolly is professor of political science at Johns Hopkins University. Many liberal secularists decry this trend, rejecting any interaction between politics and religion.

It views itself as the answer to religious wars, religious hegemony, and totalitarianism.

Why I Am Not a Secularist | Political Science | Johns Hopkins University

He calls secularists to take a closer look at the history of secularism and encourages them to be more open to hearing metaphysical and religious beliefs. Nancy Sue Love – – Hypatia 17 4: Penguin, You could not ehy signed in. Sign in via your Institution Sign in.

Books by William E.


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Boesenbergia pandurata (Roxb.) Schltr. is a tropical plant that has been used as a spice and in traditional medicine. B. pandurata contains various bioactive. This plant has 8 different botanical names which are Boesenbergia cochinchinensis (Gagnep.) Loes., Boesenbergia pandurata (Roxb.) Schltr. The medicinal plant, Boesenbergia pandurata (Roxb.) Schltr., has been reported to possess anti-oxidative and anti-inflammatory properties;.

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These results were reconfirmed in [ 89 ].

Free-radicals are known causes of pathological disturbances such as atherosclerosis and myocardial infarction. Alston Kaempferia cochinchinensis Gagnep. Received Dec 15; Accepted Jan For oral uses, rhizomes of Krachai can be used as medicine to heal mouth illness such as oral eczema, mouth ulcer and dry mouth.

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Journal of Oral Science. The CE prevents loss of water from the body and is formed by cross-linking of several proteins.

African Journal of Biotechnology. In Thai cookingfingerroot it is called krachai Thai: The BPE and panduratin A treatments increased the levels of filaggrin through up-regulating the expression of matriptase and prostasin and also boexenbergia level of caspase The CE is a structure that prevents loss of water from the body, and it is formed by cross-linking of several proteins. Trends Research in Science and Technology. Schlecht from Malaysia, Indonesia and Thailand.

This herbal plant is also used as a traditional medicine to treat illnesses such as rheumatism, muscle pain, febrifuge, gout, gastrointestinal disorders, flatulence, carminative, stomach ache, dyspepsia, and peptic ulcer.

Anti-inflammatory effects of compounds from Kaempferia parviflora and Boesenbergia pandurata. Its leaves boeesnbergia used by locals to alleviate food allergic and poisoning. Purification of methanolic extract of B. Towards synthesis of kavalactone derivatives. This compound also showed similar inhibitory activity towards S.

National Center for Biotechnology InformationU. The anti-HIV protease activity of B. Although the processes of filaggrin formation from profilaggrin are not well-established, the role of serine proteases like matriptase and prostasin in filaggrin formation has been well recognized In another study, four flavonoids, namely, pinostrobin, pinocembrin, cardamonin, and alpinetin, were isolated from the ethanolic extract of B.

Derivative of kavalactones such as 5,6-dehydrokavain has been found in B. Given the positive findings regarding the inhibitory activity of B.

These results demonstrate that BPE and panduratin A stimulate the formation of both filaggrin and NMF by elevating profilaggrin processing enzymes and caspase Prev Nutr Food Sci. The chloroform extracts of B.

The authors used the concentration of phenolic compounds as a measure of the secondary metabolism level and found that it was significantly higher than in the control when treated with ethephon. In the present study, we report whether BPE and panduratin A improve skin hydration and barrier function by assessing CE formation and filaggrin processing in HaCaT, human epidermal keratinocytes.

Chemical constituents variations of essential oils from rhizomes of four Zingiberaceae species.

Spice Pages: Fingerroot (Boesenbergia pandurata, krachai, Chinese ginger)

From Ethnomedicine to Drug Discovery”. The rhizomes are commonly used as vegetables in main dishes or eaten raw when young. Involucrin functions as an early component of CE, attaching to the membrane of keratinocytes during CE formation. It is widely used in Javanese cuisine in Indonesia.

Pathogenic bacteria are a group of bacteria that induce diseases in humans and plants. Culinary Australian Bangladeshi Indian Pakistani. Analysis of antioxidant activities contained in the Boesenbergia pandurata Schult. The vast biological activities exhibited by the compounds obtained from B. Its leaves are broad and light green while the leaf sheath is red.

Amoebiasis is an infection caused by the amoeba Entamoeba histolyticawhich typically causes acute and chronic diarrhoea in HIV patients, regardless of whether they have AIDS. Versatile asymmetric synthesis of the kavalactones: Some bioactive compounds of B.

Herunsalee et al, [ 20 ]. American Journal of Botany. The morphology of B. Nevertheless, cookbooks often prove guilty in confusing it with related rhizome spices, particularly the Indonesian spice lesser galangawhose name kencur often in Dutch spelling kentjoer is often misapplied to fingerroot.


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Lafosse was Professor of Trombone at the Conservatoire de Paris from towhere he took over from Henri Couillaud. Have one to sell? Add to basket. Add to Watch list Watching Watch list is full.

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In the s and s he recorded in orchestras with Trokbone. A brand-new, unused, unopened and undamaged item. Get the item you ordered or your money back. We may upgrade postage by altering it at our discretion, but cannot be expected to without charge – please ask for an invoice if anndre postage option you want is not offered. Description Postage and payments. This article includes a list of referencesrelated reading or external linksbut its sources remain unclear because it lacks inline citations.

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Page 1. Page 2. Page 3. Page 4. Page 5. Page 6. Page 7. Page 8. Page 9. Page Page Page Page Page Page Page By Shaykhul-Islaam Ibn Taymiyyah. of Allaah in accordance with the condition of the heart, not by their number or form Diseases of the Hearts & Their Cures. Read Diseases of the heart and their cures by Ibn Taymiyyah. This is a balagha. net exclusive! Indeed there is in the body a piece of flesh which if it is sound then .

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Should he give a lecture on religions and sects, none was seen who was more comprehensive or meticulous than he.

What has been given to them of precedence and blessings’ So they find no need of that which has been given the Muhdjirun of wealth and rank even though jealousy arises over these sorts of things. Learn more about Amazon Prime. May Allah reward the sellers and the sheikh. Farrukh, Khayats, ] 2. We have put coverings over their hearts lest they should understand it and deafness in their ears. May Allah bestow His mercy upon him.

Diseases of the Hearts & Their Cures – English – Sheikh-ul-Islam ibn Taymiyyah

He asked his Companions, ‘Do you find that I have a concession for performing fayammum? He died in the year H. And Allah will indeed allow all of this to be preserved by him. So the first type of heart is the living, humble, soft and gentle heart. The word Cudes is derived from the verb shatana which means to be distant, and indeed Shaytan is distant from all good.

[Book Study] Diseases of the Hearts and Their Cures – Imam Ibn Taymiyyah

He died in the year 74H. Allah does not ac- cept any action until both these pre-requisites are met. He was constantly in a state of dhikr and had an intense love for Allah. It is possible that a person give to those lesser than him who would help him achieve his objectives and yet display jealousy to those of the same level as him just as it is possible for him to be miserly without displaying envy to others.

He and his father were Compan- ions. In the authentic hadith, The similitude of a house in which Allah is men- tioned, and the house in which Allah is not men- tioned is as the living and the dead. It contains jealousy, arrogance, self-amazement, and love of ranking through attain- ing leadership: Truly, Yusuf and his brother are loved more by our father than we Get to Know Us.

The Messengers were sent to affirm and re-establish the natu- ral disposition and to perfect it, not to alter it. Whosoever associates with him and knows him well accuses me of falling short with regards to him. Mixing with the person who has this heart is a sickness, inter- acting with him is poison, and sitting with him is ruin. The non-Arabs call the season that follow winter al-Rabf because in this season the plants from which fruit is produced blossom and the leaves on the trees appear, [1.

If a misfortune befalls you, he says: ComiXology Thousands of Digital Comics. Anything that is directed to the person by Shaytan such as his making him hear certain words, or suggests to the heart such as suspicion and doubt acts as a trial for the latter two types of hearts and serves to further strengthen the living, truthful and sound heart.

Diseases of the Hearts & Their Cures

So what befell the believers came about as a result of their choosing obedience to Allah and His Messenger and it was ibbn from the afflictions that occur without the servant’s choice of the type that Yusuf was tried with, and neither of the type of his being separated from his father.

So these two diseases are the lords of all the ailments that afflict the heart Its cure lies in guidance based on knowledge. Yaymiyyah a problem loading this menu right now. East Dane Designer Men’s Fashion.

The Political Thought of ibn Taymiyyah [prof. He died in the year 93H. The life of the heart and its illumination is the cause of all good to be found in it and its death and darkness is the cause of all evil to be found in it.

Diseases of the Hearts and Their Cures: Ahmad Ibn Taymiyyah: : Books

His prayer used to diseasse very lengthy, with prolonged bowing and prostrations. People are divided into two opinions concerning passionate love: These types of sicknesses are commonly found in the heart. Read more Read less. Therefore the first type of heart is the living, humble, soft, attentive and heedful heart. This forced him to seek refuge in the prison [2.

Below is a selection of some of these statements: Jeart sermon, lecture, fiqk Friday sermon.

These in turn lead to two destructive illnesses – anger and misguidance. The ‘encased heart’ refers to the heart of the disbeliever be- cause it is wrapped by a veil and covering and hence the light of knowledge and faith cannot reach it. He died in the year 1 10H close to the age of ninety. Then if this person were to act, dictated by this jealousy, he would tymiyyah an oppressor going beyond bounds, deserving of pun- ishment unless he repents.

The close rela- tives of the killed sought healing,’ meaning healing of their grief, anger and sorrow – all of these being sufferings that occur in oneself.


Koldo Saratxaga Garrastatxu. likes. Local Business. View the profiles of people named Koldo Saratxaga. Join Facebook to connect with Koldo Saratxaga and others you may know. Facebook gives people the. Pedro Goruspe’s new book “El inconformismo de Koldo Saratxaga, semilla del éxito de Irizar Group y Ner Group” [The non-conformism of.

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For one-and-a-half years we have visited such organizations and learned from their extraordinary stories.

Bonuses and commissions were banned. The minifirms enjoyed a high level of autonomy, and were given freedom to make decisions on their projects. They had their own space and saratcaga own department with their own key. Leave a Reply Cancel reply. They understood and were grateful a few months after we made the decision.

The future and survival of the company was in serious danger.

Book launch “The non-conformism of Koldo Saratxaga” | emotional intelligent identity

The organizational growth was impressive with Irizar opening new production plants in different countries like ChinaMoroccoBrazilMexicoIndia and South-Africa Some of the results have been just as spectacular as Irizar. The Corporate Rebels are on a mission to make work more fun.

And a radical sarahxaga he made. The truth is that the Basque Country is full of cooperatives, very few if any, really are self-managed. This meant leaders published their ideas, decisions and other news in a monthly internal magazine.

Everyone was trusted to make an 8-hour workday and attendance was only known by your closest colleagues. Hi Henry, I think you should read the next blog post www. Every team member involved in manufacturing received the same salary, regardless of experience or age.

Koldo simplified the compensation policy into one with only three wage levels. While checking off their renowned Bucket List they share everything they learn. Evaluations were solely based on team performance, and individual evaluations were avoided. An almost flat organization which consisted of three main groups:. The physical space transformed as well, reflecting the new flat organizational structure. These groups consisted of multidisciplinary self-managed teams for all business functions, some kind of minifirms inside Irizar.

I think you should read the next blog post www. But still, every now and then, unknown stories pop-up and continue to amaze us. The million dollar question is how Koldo achieved such spectecular growth. For Koldo it was important that his people were building the future of Irizar instead of ssratxaga chasing a set of dictated targets. Their capacity to adapt, to understand the client, to know how, when, why, what for, was much koleo.

To control the arrival and departure of each person is easy, but not at all effective. He did this in the Basque country where co-operatives are a way of life.

Book launch “The non-conformism of Koldo Saratxaga”

In just over 10 years, Koldo and his team have helped to transform 50 organizations in the region of Bilbao. Comments He did this in the Basque country where co-operatives are a way of life. They would, for example, set their own objectives and time schedules. Team members were assigned to projects and team leaders were chosen by the team members themselves.

These factors assessed specific aspects of knowledge, service level, market share, satisfaction and financial situation of each customer. The highest paid person within the company could earn a maximum of three times the salary of the lowest paid one.

Or check out any of the more than 50 stories of companies that have done similar things including examples in London and New York. The cooperative movement is full of principles praising transparency and other democratic measures, but most of the cooperatives especially those belonging to the Mondragon group are quite hierarchical even if workers vote in reality similar to shareholders in listed companies.

When Koldo joined Irizar in the company was in deep crisis. We met with Koldo during our visit to Bilbao. What Koldo did in was radical and innovative in the Basque Country, or everywhere. From near bankruptcy to double-digit growth When Koldo joined Irizar in the company was in deep crisis. Within Irizar constant communication — both internal and external — was strongly encouraged.

So he implemented a new mission mainly to create employment and wealth through growth in the luxury coach market. Before approving both documents, Koldo encouraged everyone to discuss the documents extensively to ensure a clear and common understanding.

Stay tuned for more…. Next, he transformed their outdated management system that was composed of a traditional hierarchical structure and a clear top-down decision making process.

Koldo introduced a model at Irizar that was completely different from any other model in zaratxaga industry. After his period at Irizar, he started his own company K2K Emocionando to support other organizations to transform the way they work.

Additionally, Irizar was on the verge of bankruptcy. This happened to us again last week, when we visited Bilbao Spain.

The manufacturing and service facilities were relocated to one floor and all people mixed together on one level. Nothing should be hidden from staff. They managed to ramp up the production of coaches from to coaches a year.